486d062f78
Added section on neuronal cultures in intro. Started working on results. Added boltzman fit to Pospischil in Methods. Continued working on discussion.
26 lines
2.5 KiB
TeX
26 lines
2.5 KiB
TeX
\begin{table}[ht!]
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\centering
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\linespread{1.5}\selectfont
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\fontsize{10pt}{12pt}\selectfont{
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\begin{tabular}{c c c c c c }
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\Xhline{1\arrayrulewidth}
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& Gating & \(V_{1/2}\) [mV]& \(k\) & \(j\) & \(a\) \\
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\Xhline{1\arrayrulewidth}
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%Pospischil
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& \(\textrm{I}_{\textrm{Na}}\) activation &-34.33054521 & -8.21450277 & 1.42295686 & --- \\
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RS pyramidal, & \(\textrm{I}_{\textrm{Na}}\) inactivation &-34.51951036 & 4.04059373 & 1 & 0.05 \\
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RS inhibitory, & \(\textrm{I}_{\textrm{Kd}}\) activation &-63.76096946 & -13.83488194 & 7.35347425 & --- \\
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FS & \(\textrm{I}_{\textrm{L}}\) activation &-39.03684525 & -5.57756176 & 2.25190197 & --- \\
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& \(\textrm{I}_{\textrm{L}}\) inactivation &-57.37 & 20.98 & 1 & --- \\
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& \(\textrm{I}_{\textrm{M}}\) activation &-45 & -9.9998807337 & 1 & --- \\ %-45 with 10 mV shift to contributes to resting potential
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& & & & &\\
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\(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) & \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) activation &-30.01851852 & -7.73333333 & 1 & --- \\
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& \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) Inactivation &-46.85851852 & 7.67266667 & 1 & 0.245 \\
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\Xhline{1\arrayrulewidth}
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\end{tabular}}
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\caption[Gating Properties]{ For comparability to typical electrophysiological data fitting reported and for ease of further gating curve manipulations, a Boltzmann \(x_\infty = {\left(\frac{1-a}{1+{exp[{\frac{V-V_{1/2}}{k}}]}} +a\right)^j}\) with slope \(k\), voltage for half-maximal activation or inactivation (\(V_{1/2}\)), exponent \(j\), and persistent current \(0 \leq a \leq 1\) were fitted for the \cite{pospischil_minimal_2008} models where \(\alpha_x\) and \(\beta_x\) are used. Gating parameters for \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) are taken from \cite{ranjan_kinetic_2019} and fit to mean wild type parameters in \cite{lauxmann_therapeutic_2021}. Model gating not listed are taken directly from source publication.}
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\label{tab:gating}
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\end{table} |