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Updated appearance of units, minuses, gene names, tables, and fixed clipping issue in Fig 2.

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Added section on neuronal cultures in intro. Started working on results.
Added boltzman fit to Pospischil in Methods. Continued working on discussion.
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nkoch1 2022-04-03 19:31:10 -04:00
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\begin{table}[ht!]
\centering
\linespread{1.5}\selectfont
\fontsize{10pt}{12pt}\selectfont{
\begin{tabular}{c c c c c c }
\Xhline{1\arrayrulewidth}
& Gating & \(V_{1/2}\) [mV]& \(k\) & \(j\) & \(a\) \\
\Xhline{1\arrayrulewidth}
%Pospischil
& \(\textrm{I}_{\textrm{Na}}\) activation &-34.33054521 & -8.21450277 & 1.42295686 & --- \\
RS pyramidal, & \(\textrm{I}_{\textrm{Na}}\) inactivation &-34.51951036 & 4.04059373 & 1 & 0.05 \\
RS inhibitory, & \(\textrm{I}_{\textrm{Kd}}\) activation &-63.76096946 & -13.83488194 & 7.35347425 & --- \\
FS & \(\textrm{I}_{\textrm{L}}\) activation &-39.03684525 & -5.57756176 & 2.25190197 & --- \\
& \(\textrm{I}_{\textrm{L}}\) inactivation &-57.37 & 20.98 & 1 & --- \\
& \(\textrm{I}_{\textrm{M}}\) activation &-45 & -9.9998807337 & 1 & --- \\ %-45 with 10 mV shift to contributes to resting potential
& & & & &\\
\(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) & \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) activation &-30.01851852 & -7.73333333 & 1 & --- \\
& \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) Inactivation &-46.85851852 & 7.67266667 & 1 & 0.245 \\
\Xhline{1\arrayrulewidth}
\end{tabular}}
\caption[Gating Properties]{ For comparability to typical electrophysiological data fitting reported and for ease of further gating curve manipulations, a Boltzmann \(x_\infty = {\left(\frac{1-a}{1+{exp[{\frac{V-V_{1/2}}{k}}]}} +a\right)^j}\) with slope \(k\), voltage for half-maximal activation or inactivation (\(V_{1/2}\)), exponent \(j\), and persistent current \(0 \leq a \leq 1\) were fitted for the \cite{pospischil_minimal_2008} models where \(\alpha_x\) and \(\beta_x\) are used. Gating parameters for \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) are taken from \cite{ranjan_kinetic_2019} and fit to mean wild type parameters in \cite{lauxmann_therapeutic_2021}. Model gating not listed are taken directly from source publication.}
\label{tab:gating}
\end{table}