From 486d062f78d5033a95c49dca3ba1a757011bcb84 Mon Sep 17 00:00:00 2001 From: nkoch1 Date: Sun, 3 Apr 2022 19:31:10 -0400 Subject: [PATCH] Updated appearance of units, minuses, gene names, tables, and fixed clipping issue in Fig 2. Added section on neuronal cultures in intro. Started working on results. Added boltzman fit to Pospischil in Methods. Continued working on discussion. --- gating_table.tex | 26 ++++++++++++++++++++++++++ 1 file changed, 26 insertions(+) create mode 100644 gating_table.tex diff --git a/gating_table.tex b/gating_table.tex new file mode 100644 index 0000000..ce90b5f --- /dev/null +++ b/gating_table.tex @@ -0,0 +1,26 @@ +\begin{table}[ht!] + + \centering + \linespread{1.5}\selectfont + \fontsize{10pt}{12pt}\selectfont{ + \begin{tabular}{c c c c c c } + \Xhline{1\arrayrulewidth} + & Gating & \(V_{1/2}\) [mV]& \(k\) & \(j\) & \(a\) \\ + \Xhline{1\arrayrulewidth} + %Pospischil + & \(\textrm{I}_{\textrm{Na}}\) activation &-34.33054521 & -8.21450277 & 1.42295686 & --- \\ +RS pyramidal, & \(\textrm{I}_{\textrm{Na}}\) inactivation &-34.51951036 & 4.04059373 & 1 & 0.05 \\ + RS inhibitory, & \(\textrm{I}_{\textrm{Kd}}\) activation &-63.76096946 & -13.83488194 & 7.35347425 & --- \\ + FS & \(\textrm{I}_{\textrm{L}}\) activation &-39.03684525 & -5.57756176 & 2.25190197 & --- \\ + & \(\textrm{I}_{\textrm{L}}\) inactivation &-57.37 & 20.98 & 1 & --- \\ + & \(\textrm{I}_{\textrm{M}}\) activation &-45 & -9.9998807337 & 1 & --- \\ %-45 with 10 mV shift to contributes to resting potential + & & & & &\\ + \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) & \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) activation &-30.01851852 & -7.73333333 & 1 & --- \\ + & \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) Inactivation &-46.85851852 & 7.67266667 & 1 & 0.245 \\ + \Xhline{1\arrayrulewidth} + + + \end{tabular}} + \caption[Gating Properties]{ For comparability to typical electrophysiological data fitting reported and for ease of further gating curve manipulations, a Boltzmann \(x_\infty = {\left(\frac{1-a}{1+{exp[{\frac{V-V_{1/2}}{k}}]}} +a\right)^j}\) with slope \(k\), voltage for half-maximal activation or inactivation (\(V_{1/2}\)), exponent \(j\), and persistent current \(0 \leq a \leq 1\) were fitted for the \cite{pospischil_minimal_2008} models where \(\alpha_x\) and \(\beta_x\) are used. Gating parameters for \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) are taken from \cite{ranjan_kinetic_2019} and fit to mean wild type parameters in \cite{lauxmann_therapeutic_2021}. Model gating not listed are taken directly from source publication.} + \label{tab:gating} +\end{table} \ No newline at end of file