model_mutations_2022/Code/README.md

Python code repository for Koch et al. 2022

Modelling on the effects of ion current property changes on firing behaviour in diverse neuronal models and in with Kv1.1 mutations that cause episodic ataxia type 1.

./Functions

• Python function files for models
  • RS pyramidal, RS inhibitory and FS from Pospischil et al. (2008)
  • Cb stellate from Alexander et al. (2019) with and without added Kv1.1
  • STN from Otsuka et al. (2004) with and without added Kv1.1
• Utility_fxns.py for common useful functions

./Neuron_models

• Scripts for simulation of each model to current steps and ramp currents

./Sensitivity_Analysis

• Scripts for sensitivity analysis in each model

./KCNA1_mutations

• Scripts for simulation of KCNA1 mutations described in Lauxmann et al. (2021)