28 lines
2.6 KiB
TeX
28 lines
2.6 KiB
TeX
\begin{table}[ht!]
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\centering
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\linespread{1.5}\selectfont
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\fontsize{10pt}{12pt}\selectfont{
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\begin{tabular}{c c c c c c }
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\Xhline{1\arrayrulewidth}
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& Gating & \(V_{1/2}\) [mV]& \(k\) & \(j\) & \(a\) \\
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\Xhline{1\arrayrulewidth}
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%Pospischil
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& \(\textrm{I}_{\textrm{Na}}\) activation &$-34.33054521$ & $-8.21450277$ & $1.42295686$ & --- \\
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RS pyramidal, & \(\textrm{I}_{\textrm{Na}}\) inactivation &$-34.51951036$ & $4.04059373$ & $1$ & $0.05$ \\
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RS inhibitory, & \(\textrm{I}_{\textrm{Kd}}\) activation &$-63.76096946$ & $-13.83488194$ & $7.35347425$ & --- \\
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FS & \(\textrm{I}_{\textrm{L}}\) activation &$-39.03684525$ & $-5.57756176$ & $2.25190197$ & --- \\
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& \(\textrm{I}_{\textrm{L}}\) inactivation &$-57.37$ & $20.98$ & $1$ & --- \\
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& \(\textrm{I}_{\textrm{M}}\) activation &$-45$ & $-9.9998807337$ & $1$ & --- \\ %-45 with 10 mV shift to contributes to resting potential
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% & & & & &\\
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\Xhline{1\arrayrulewidth}
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\(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) & \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) activation &$-30.01851852$ & $-7.73333333$ & $1$ & --- \\
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& \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) Inactivation &$-46.85851852$ & $7.67266667$ & $1$ & $0.245$ \\
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\Xhline{1\arrayrulewidth}
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\end{tabular}}
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\caption[Gating Properties]{ For comparability to typical electrophysiological data fitting reported and for ease of further gating curve manipulations, a sigmoid function (Eqn.\ref{eqn:Boltz}) %Boltzmann \(x_\infty = {\left(\frac{1-a}{1+{exp[{\frac{V-V_{1/2}}{k}}]}} +a\right)^j}\)
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with slope \(k\), voltage for half-maximal activation or inactivation (\(V_{1/2}\)), exponent \(j\), and persistent current \(0 \leq a \leq 1\) were fitted for the \citet{pospischil_minimal_2008} models where \(\alpha_x\) and \(\beta_x\) are used. Gating parameters for \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) are taken from \citet{ranjan_kinetic_2019} and fit to mean wild type parameters in \citet{lauxmann_therapeutic_2021}. Model gating parameters not listed are taken directly from source publication.}
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\label{tab:gating}
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\end{table} |