\begin{table}[ht!] \centering \linespread{1.5}\selectfont \fontsize{10pt}{12pt}\selectfont{ \begin{tabular}{c c c c c c } \Xhline{1\arrayrulewidth} & Gating & \(V_{1/2}\) [mV]& \(k\) & \(j\) & \(a\) \\ \Xhline{1\arrayrulewidth} %Pospischil & \(\textrm{I}_{\textrm{Na}}\) activation &$-34.33054521$ & $-8.21450277$ & $1.42295686$ & --- \\ RS pyramidal, & \(\textrm{I}_{\textrm{Na}}\) inactivation &$-34.51951036$ & $4.04059373$ & $1$ & $0.05$ \\ RS inhibitory, & \(\textrm{I}_{\textrm{Kd}}\) activation &$-63.76096946$ & $-13.83488194$ & $7.35347425$ & --- \\ FS & \(\textrm{I}_{\textrm{L}}\) activation &$-39.03684525$ & $-5.57756176$ & $2.25190197$ & --- \\ & \(\textrm{I}_{\textrm{L}}\) inactivation &$-57.37$ & $20.98$ & $1$ & --- \\ & \(\textrm{I}_{\textrm{M}}\) activation &$-45$ & $-9.9998807337$ & $1$ & --- \\ %-45 with 10 mV shift to contributes to resting potential % & & & & &\\ \Xhline{1\arrayrulewidth} \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) & \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) activation &$-30.01851852$ & $-7.73333333$ & $1$ & --- \\ & \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) Inactivation &$-46.85851852$ & $7.67266667$ & $1$ & $0.245$ \\ \Xhline{1\arrayrulewidth} \end{tabular}} \caption[Gating Properties]{ For comparability to typical electrophysiological data fitting reported and for ease of further gating curve manipulations, a sigmoid function (Eqn.\ref{eqn:Boltz}) %Boltzmann \(x_\infty = {\left(\frac{1-a}{1+{exp[{\frac{V-V_{1/2}}{k}}]}} +a\right)^j}\) with slope \(k\), voltage for half-maximal activation or inactivation (\(V_{1/2}\)), exponent \(j\), and persistent current \(0 \leq a \leq 1\) were fitted for the \citet{pospischil_minimal_2008} models where \(\alpha_x\) and \(\beta_x\) are used. Gating parameters for \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) are taken from \citet{ranjan_kinetic_2019} and fit to mean wild type parameters in \citet{lauxmann_therapeutic_2021}. Model gating parameters not listed are taken directly from source publication.} \label{tab:gating} \end{table}