added some citations, papers
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@ -120,9 +120,9 @@ Although the effects of channelopathies on ion current kinetics are frequently a
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%General understanding of the effects of changes in current properties on neuronal firing may help to fill the need to understand the impacts of ion channel mutations on neuronal firing.
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However the effect of a given channelopathy on different neuronal types across the brain is often unclear and not feasible to experimentally obtain. Different neuron types have different ion current compositions \textcolor{red}{(cite Berens and Allan Institute)} and therefore likely respond differently to changes in the properties of one current.
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However the effect of a given channelopathy on different neuronal types across the brain is often unclear and not feasible to experimentally obtain. Different neuron types have different ion current compositions \citep{yao2021taxonomy} \textcolor{red}{(cite Berens)} and therefore likely respond differently to changes in the properties of one current.
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% \textcolor{red}{In the simplest case, the influence on the firing behaviour should correlate with the expression level of the affected gene \textcolor{red}{(cite Niko , other Papers)}. But if a \textcolor{red}{ kinetic parameter} is changed too much, it can have unforseen consequences. }
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The expression level of an affected gene can correlate with firing behaviour in the simplest case \textcolor{red}{(cite Niko - this one \citep{Layer2021}?, other Papers)}, however if a gating property is altered substantially this can have complex consequences.
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The expression level of an affected gene can correlate with firing behaviour in the simplest case \citep{Layer2021} \textcolor{red}{(cite other Papers?)}, however if a gating property is altered substantially this can have complex consequences.
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For instance, altering relative current amplitudes can dramatically influence the firing behaviour and dynamics of neurons \citep{rutecki_neuronal_1992, pospischil_minimal_2008,Kispersky2012, golowasch_failure_2002, barreiro_-current_2012, Noebels2017, Layer2021}, however other current parameters impact neuronal firing as well. In extreme cases, a mutation can have opposite effects on different neuron types. For example, the R1629H SCN1A mutation is associated which increased firing in interneurons, but decreases pyramidal neuron excitability \citep{Hedrich14874}\textcolor{red}{(and the other paper?)}. %not sure which paper you mean Lukas
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ref.bib
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ref.bib
@ -1390,5 +1390,19 @@ SIGNIFICANCE: Bromide is most effective and is a well-tolerated drug among DS pa
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}
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@article{yao2021taxonomy,
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title={A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation},
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author={Yao, Zizhen and van Velthoven, Cindy TJ and Nguyen, Thuc Nghi and Goldy, Jeff and Sedeno-Cortes, Adriana E and Baftizadeh, Fahimeh and Bertagnolli, Darren and Casper, Tamara and Chiang, Megan and Crichton, Kirsten and others},
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doi={10.1101/2020.03.30.015214},
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url={https://www.sciencedirect.com/science/article/abs/pii/S0092867421005018},
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journal={Cell},
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volume={184},
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number={12},
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pages={3222--3241},
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year={2021},
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publisher={Elsevier}
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}
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@Comment{jabref-meta: databaseType:bibtex;}
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