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added some citations, papers

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sonnenberg 2022-05-04 11:04:58 +02:00
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manuscript.tex
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@ -120,9 +120,9 @@ Although the effects of channelopathies on ion current kinetics are frequently a
%General understanding of the effects of changes in current properties on neuronal firing may help to fill the need to understand the impacts of ion channel mutations on neuronal firing.
However the effect of a given channelopathy on different neuronal types across the brain is often unclear and not feasible to experimentally obtain. Different neuron types have different ion current compositions \textcolor{red}{(cite Berens and Allan Institute)} and therefore likely respond differently to changes in the properties of one current.
However the effect of a given channelopathy on different neuronal types across the brain is often unclear and not feasible to experimentally obtain. Different neuron types have different ion current compositions \citep{yao2021taxonomy} \textcolor{red}{(cite Berens)} and therefore likely respond differently to changes in the properties of one current.
% \textcolor{red}{In the simplest case, the influence on the firing behaviour should correlate with the expression level of the affected gene \textcolor{red}{(cite Niko , other Papers)}. But if a \textcolor{red}{ kinetic parameter} is changed too much, it can have unforseen consequences. }
The expression level of an affected gene can correlate with firing behaviour in the simplest case \textcolor{red}{(cite Niko - this one \citep{Layer2021}?, other Papers)}, however if a gating property is altered substantially this can have complex consequences.
The expression level of an affected gene can correlate with firing behaviour in the simplest case \citep{Layer2021} \textcolor{red}{(cite other Papers?)}, however if a gating property is altered substantially this can have complex consequences.
For instance, altering relative current amplitudes can dramatically influence the firing behaviour and dynamics of neurons \citep{rutecki_neuronal_1992, pospischil_minimal_2008,Kispersky2012, golowasch_failure_2002, barreiro_-current_2012, Noebels2017, Layer2021}, however other current parameters impact neuronal firing as well. In extreme cases, a mutation can have opposite effects on different neuron types. For example, the R1629H SCN1A mutation is associated which increased firing in interneurons, but decreases pyramidal neuron excitability \citep{Hedrich14874}\textcolor{red}{(and the other paper?)}. %not sure which paper you mean Lukas

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ref.bib
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@ -1390,5 +1390,19 @@ SIGNIFICANCE: Bromide is most effective and is a well-tolerated drug among DS pa
}
@article{yao2021taxonomy,
title={A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation},
author={Yao, Zizhen and van Velthoven, Cindy TJ and Nguyen, Thuc Nghi and Goldy, Jeff and Sedeno-Cortes, Adriana E and Baftizadeh, Fahimeh and Bertagnolli, Darren and Casper, Tamara and Chiang, Megan and Crichton, Kirsten and others},
doi={10.1101/2020.03.30.015214},
url={https://www.sciencedirect.com/science/article/abs/pii/S0092867421005018},
journal={Cell},
volume={184},
number={12},
pages={3222--3241},
year={2021},
publisher={Elsevier}
}
@Comment{jabref-meta: databaseType:bibtex;}