diff --git a/scientificcomputing-script.tex b/scientificcomputing-script.tex index 64db445..ee064c9 100644 --- a/scientificcomputing-script.tex +++ b/scientificcomputing-script.tex @@ -46,6 +46,10 @@ % - data analysis skills way beyond basic statistical test are at the % core of modern neuroscience % - *understanding* of basic concepts of data analysis concepts is important +% - math is the universal language of natural sciences, including neuroscience. +% it is the most precise way to express relation. +% We therefore expose you to some mathematical equations +% that do not go beyond what you learned at school. % - most concepts are also quite relevant for the brain itself! % - modern approaches: % * open source science (open data, open code, open algorithmns in contrast diff --git a/simulations/lecture/simulations.tex b/simulations/lecture/simulations.tex index c4dbfa1..7f91e19 100644 --- a/simulations/lecture/simulations.tex +++ b/simulations/lecture/simulations.tex @@ -160,6 +160,13 @@ corresponding standard deviation equal the inverse rate. values. \end{exercise} + +\subsection{Uniformly distributed random numbers} + +\begin{figure}[t] + Exponential distribution of ISIs. +\end{figure} + The \code{rand()} function returns uniformly distributed random numbers between zero and one \begin{equation} @@ -201,12 +208,40 @@ the event does not occur. probability of $P=0.6$. Count the number of heads. \end{exercise} -Random walk! Have a figure with a few 1D random walks and the -increasing standard deviation as a sheded area behind. +\subsection{Random walks} +A basic concept for stochastic models is the random walk. A walker +starts at some initial position $x_0$. It then takes steps to the +right, $x_n = x_{n-1} + 1$, with some probability $P_r$ or to the +left, $x_n = x_{n-1} - 1$, with probability $P_l = 1-P_r$. +For a symmetric random walk, the probabilities to step to the left or +to the right are the same, $P_r = P_l = \frac{1}{2}$. The average +position of many walkers is then independent of the iteration step and +equals the initial position $x_0$. The standard deviation of the +walker positions, however, grows with the square root of the number of +iteration steps $n$: $\sigma_{x_n} = \sqrt{n}$. +\begin{figure}[tb] + Have a figure with a few 1D random walks and the increasing standard + deviation as a shaded area behind. And with absorbing boundary. +\end{figure} +The sub-threshold membrane potential of a neuron can be modeled as a +one-dimensional random walk. The thousands of excitatory and +inhibitory synaptic inputs of a principal neuron in the brain make the +membrane potential to randomly step upwards or downwards. Once the +membrane potential hits a firing threshold an action potential is +generated and the membrane potential is reset to the resting +potential. The firing threshold in this context is often called an +``absorbing boundary''. The time it takes from the initial position to +cross the threshold is the ``first-passage time''. For neurons this is +the interspike interval. For symmetric random walks the first-passage +times are again exponentially distributed. ??? Is that so ??? + +% Gerstein and Mandelbrot 1964 + +Higher dimensions, Brownian motion. The gamma distribution (\code{gamrnd()}) phenomenologically describes