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sonnenberg
2020-01-16 14:01:29 +01:00
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projects/project_activation_curve/activation_curve.tex
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\section{Estimation of the activation curve}
Mutations in genes, encoding for ion channels, can result in a variety of neurological diseases like epilepsy, autism and intellectual disability. One way to find a possible treatment is to compare the voltage dependent kinetics of the mutated channel with its corresponding wild-type. These kinetics are described in voltage-clamp experiments and the subsequent data analysis.
In this task you will compute and compare the activation curves of the Nav1.6 wild-type channel and one with a mutation named A1622D (the amino acid Alanine (A) at the 1622nd position is replaced by Aspartic acid (D)) that causes intellectual disability in humans.
In this task you will compute and compare the activation curves of the Nav1.6 wild-type channel and a variation named A1622D (the amino acid Alanine (A) at the 1622nd position is replaced by Aspartic acid (D)) that causes intellectual disability in humans.