This commit is contained in:
2020-01-16 14:01:29 +01:00
30 changed files with 543 additions and 730 deletions

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For new projects:
Copy project_template/ and adapt according to your needs
All projects:
check for time information
1) project_activation_curve
medium
Write questions
project_adaptation_fit
2) project_adaptation_fit
OK, medium
Add plotting of cost function
project_eod
3) project_eod
OK, medium - difficult
b_0 is not defined
project_eyetracker
4) project_eyetracker
OK, difficult
no statistics, but kmeans
project_fano_slope
5) project_face_selectivity
medium-difficult
(Marius monkey data)
6) project_fano_slope
OK, difficult
project_fano_test
7) project_fano_test
OK -
project_fano_time
8) project_fano_time
OK, medium-difficult
project_ficurves
9) project_ficurves
OK, medium
Maybe add correlation test or fit statistics
project_input_resistance
10) project_input_resistance
medium
What is the problem with this project? --> No difference between segments
Improve questions
project_isicorrelations
11) project_isicorrelations
medium-difficult
Need to finish solution
project_isipdffit
12) project_isipdffit
Too technical
project_lif
13) project_lif
OK, difficult
no statistics
project_mutualinfo
14) project_mutualinfo
OK, medium
project_noiseficurves
15) project_noiseficurves
OK, simple-medium
no statistics
project_numbers
16) project_numbers
simple
We might add some more involved statistical analysis
project_pca_natural_images
17) project_pca_natural_images
medium
Make a solution (->Lukas)
project_photoreceptor
18) project_photoreceptor
OK, simple
project_populationvector
19) project_populationvector
difficult
OK
project_qvalues
20) project_power_analysis
medium
21) project_qvalues
-
Interesting! But needs solution.
project_random_walk
22) project_random_walk
simple-medium
project_serialcorrelation
23) project_serialcorrelation
OK, simple-medium
project_spectra
24) project_shorttermpotentiation
Write questions
25) project_spectra
-
Needs improvements and a solution
project_stimulus_reconstruction
26) project_stimulus_reconstruction
OK, difficult
project_vector_strength
27) project_vector_strength
OK, medium-difficult
project_power_analysis
medium
Marius monkey data:
medium-difficult

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\section{Estimation of the activation curve}
Mutations in genes, encoding for ion channels, can result in a variety of neurological diseases like epilepsy, autism and intellectual disability. One way to find a possible treatment is to compare the voltage dependent kinetics of the mutated channel with its corresponding wild-type. These kinetics are described in voltage-clamp experiments and the subsequent data analysis.
In this task you will compute and compare the activation curves of the Nav1.6 wild-type channel and one with a mutation named A1622D (the amino acid Alanine (A) at the 1622nd position is replaced by Aspartic acid (D)) that causes intellectual disability in humans.
In this task you will compute and compare the activation curves of the Nav1.6 wild-type channel and a variation named A1622D (the amino acid Alanine (A) at the 1622nd position is replaced by Aspartic acid (D)) that causes intellectual disability in humans.