\begin{table}[ht!] \centering \linespread{1.5}\selectfont \fontsize{10pt}{12pt}\selectfont{ \begin{tabular}{c c c c c c } \Xhline{1\arrayrulewidth} & Gating & \(V_{1/2}\) [mV]& \(k\) & \(j\) & \(a\) \\ \Xhline{1\arrayrulewidth} %Pospischil & \(\textrm{I}_{\textrm{Na}}\) activation &\(-34.33054521\) & \(-8.21450277\) & \(1.42295686\) & --- \\ RS pyramidal, & \(\textrm{I}_{\textrm{Na}}\) inactivation &\(-34.51951036\) & \(4.04059373\) & \(1\) & \(0.05\) \\ RS inhibitory, & \(\textrm{I}_{\textrm{Kd}}\) activation &\(-63.76096946\) & \(-13.83488194\) & \(7.35347425\) & --- \\ FS & \(\textrm{I}_{\textrm{L}}\) activation &\(-39.03684525\) & \(-5.57756176\) & \(2.25190197\) & --- \\ & \(\textrm{I}_{\textrm{L}}\) inactivation &\(-57.37\) & \(20.98\) & \(1\) & --- \\ & \(\textrm{I}_{\textrm{M}}\) activation &\(-45\) & \(-9.9998807337\) & \(1\) & --- \\ %-45 with 10 mV shift to contributes to resting potential % & & & & &\\ \Xhline{1\arrayrulewidth} \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) & \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) activation &\(-30.01851852\) & \(-7.73333333\) & \(1\) & --- \\ & \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) Inactivation &\(-46.85851852\) & \(7.67266667\) & \(1\) & \(0.245\) \\ \Xhline{1\arrayrulewidth} \end{tabular}} \caption[Gating Properties]{ For comparability to typical electrophysiological data fitting reported and for ease of further gating curve manipulations, a sigmoid function (Eqn.\ref{eqn:Boltz}) %Boltzmann \(x_\infty = {\left(\frac{1-a}{1+{exp[{\frac{V-V_{1/2}}{k}}]}} +a\right)^j}\) with slope \(k\), voltage for half-maximal activation or inactivation (\(V_{1/2}\)), exponent \(j\), and persistent current \(0 \leq a \leq 1\) were fitted for the \citet{pospischil_minimal_2008} models where \(\alpha_x\) and \(\beta_x\) are used. Gating parameters for \(\textrm{I}_{\textrm{K}_{\textrm{V}}\textrm{1.1}}\ \) are taken from \citet{ranjan_kinetic_2019} and fit to mean wild type parameters in \citet{lauxmann_therapeutic_2021}. Model gating parameters not listed are taken directly from source publication.} \label{tab:gating} \end{table}