% Created 2022-02-16 Wed 15:43
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\author{Nils  Koch}
\date{}
\title{Figure update}
\subtitle{}
\hypersetup{
 pdfauthor={Nils  Koch},
 pdftitle={Figure update},
 pdfkeywords={},
 pdfsubject={},
 pdfcreator={Emacs 27.2 (Org mode 9.4.4)}, 
 pdflang={English}}
\begin{document}

\maketitle

\section{Introduction}
\label{sec:orgaa79910}
\begin{frame}[label={sec:org5e30c84}]{Intro to org to Beamer}
\begin{itemize}
\item This is not that visually appealling, but I haven't taken the time to set the colors and style to my liking in the Latex header
\item I have tried to include as many examples of things I find useful as possible
\begin{itemize}
\item sometimes this makes the slide not make much sense, but the example of how to do things is hopefully useful
\end{itemize}
\item The only slight pain with using org for both Beamer and normal Latex pdf is:
\begin{itemize}
\item you cannot have the pdf open in some pdf viewers and export to it (eg adobe)
\item I use Sumatra (\url{https://www.sumatrapdfreader.org/free-pdf-reader})
\begin{itemize}
\item can have your pdf open in sumatra, export to it and it will update the pdf to the new exported file while open
\end{itemize}
\end{itemize}
\end{itemize}
\end{frame}

\section{Figure update}
\label{sec:orgf0c258a}
\begin{frame}[label={sec:orgbc00e40}]{Firing Characterization}
\vspace{-0.5cm}
\begin{columns}
\begin{column}[t]{0.65\columnwidth}
\begin{itemize}
\item Firing is a complicated phenomenon
\item How to best characterize it?
\begin{itemize}
\item rheobase
\item AUC
\end{itemize}
\end{itemize}
\end{column}
\begin{column}[t]{0.35\columnwidth}
\begin{center}
\includegraphics[width=0.95\textwidth]{firing_characterization.pdf}
\end{center}
\end{column}
\end{columns}
\end{frame}

\begin{frame}[label={sec:org30ceea9}]{Diversity in Firing Properties of the Models}
\begin{center}
\includegraphics[width=0.55\textwidth]{diversity_in_firing.pdf}
\end{center}
\end{frame}

\begin{frame}[label={sec:org2ecf870}]{Sensitivy analysis: OFAT}
\vspace{-2cm}
\begin{itemize}
\item[{$\square$}] one factor at a time sensitivity analysis
\item simulate firing responses
\begin{itemize}
\item compute fI curves
\begin{itemize}
\item get rheobase
\item compute AUC
\end{itemize}
\end{itemize}
\end{itemize}
\end{frame}
\begin{frame}[label={sec:orgd668fd1}]{Rheobase sensitivity Analysis}
\begin{center}
\includegraphics[width=0.85\textwidth]{rheobase_correlation.pdf}
\end{center}
\tiny Koch et al. 2022
\end{frame}
\begin{frame}[label={sec:orgb070147}]{AUC Sensitivity Analysis}
\begin{itemize}
\item AUC = area under the curve
\end{itemize}
\begin{center}
\includegraphics[width=0.75\textwidth]{AUC_correlation.pdf}
\end{center}
\begin{itemize}
\item AUC over the initial non-zero fI curve is a proxy for slope
\end{itemize}
\end{frame}

\begin{frame}[label={sec:orgb9500d1}]{\(K_V1.1\) Mutations}
\begin{center}
\includegraphics[width=0.95\textwidth]{simulation_model_comparison.pdf}
\end{center}
\end{frame}

\begin{frame}[label={sec:orga5c8265}]{Ramp Firing}
\begin{center}
\includegraphics[width=0.95\textwidth]{ramp_firing.pdf}
\end{center}
\end{frame}
\end{document}