diff --git a/manuscript.tex b/manuscript.tex index 85528db..85290d1 100644 --- a/manuscript.tex +++ b/manuscript.tex @@ -321,11 +321,11 @@ Qualitative differences can be found, for example, when increasing the maximal c \\\notejb{tick labels too small!}\notenk{Is this better?}\notejb{Make them as large as possible. You still have a bit of room before they start overlapping.} % \\\notejb{The colored boxes need to be a bit higher with the topic edge having some distance to the plot title}\notenk{done!} \\\notejb{To make referencing in the text simpler we should tag each panel} \notenk{done? I think} - \\\notenk{Re-work legend to be in line with new figure} + \\\notenk{New legend for new figure} % \\\notejb{second column: x-label are wrong, i.e. $k/k_{WT}$, $g/g_{WT}$}\notenk{done} % \\\notejb{Make subplot size exactly like in Figure 4}\notenk{done} \linespread{1.}\selectfont - \caption[]{Effects of altered channel kinetics on AUC in various neuron models. The Kendall rank correlation (Kendall \(\tau\)) coefficients between shifts in \(V_{1/2}\) and AUC, slope factor k and AUC as well as maximal current conductances and AUC for each model are shown on the right in (A), (B) and (C) respectively. The relationships between AUC and \(\Delta V_{1/2}\), slope (k) and maximal conductance (g) for the Kendall \(\tau\) coefficients highlights by the black box are depicted in the middle panel. The fI curves corresponding to one of the models are shown in the left panels.} + \caption[]{Effects of altered channel kinetics on AUC in various neuron models. The fI curves corresponding to shifts in FS \(+\)\Kv model delayed rectifier K half activation \(V_{1/2}\) (A), changes \Kv activation slope factor \(k\) in the FS \(+\)\Kv model (B), and changes in maximal conductance of delayed rectifier K current in the STN \(+\)\Kv model (C) are shown. The \ndAUC of fI curves is plotted against delayed rectifier K half activation potential (\(\Delta V_{1/2}\); B), \Kv activation slope factor \(k\) (k/\(\textrm{k}_{WT}\); E) and maximal conductance \(g\) of the delayed rectifier K current (g/\(\textrm{g}_{WT}\); H) for all models (thin lines) with relationships from the fI curve examples (A, D, G respectively) highlighted by thick lines with colors corresponding to the box highlighting each set of fI curves. The Kendall rank correlation (Kendall \(\tau\)) coefficients between shifts in half maximal potential \(V_{1/2}\) and \ndAUC (C), slope factor k and \ndAUC (F) as well as maximal current conductances and \ndAUC (I) for each model and current property is computed. The relationships between \(\Delta V_{1/2}\), k/\(\textrm{k}_{WT}\), and g/\(\textrm{g}_{WT}\) and \ndAUC for the Kendall rank correlations highlighted in the black boxes are depicted in (B), (E) and (H) respectively.} \label{fig:AUC_correlation} \end{figure} @@ -343,9 +343,9 @@ Although changes in half maximal potential \(V_{1/2}\) and slope factor \(k\) ge \begin{figure}[tp] \centering \includegraphics[width=\linewidth]{Figures/rheobase_correlation.pdf} - \\\notenk{Re-work legend to be in line with new figure} + \\\notenk{New legend for new figure} \linespread{1.}\selectfont - \caption[]{Effects of altered channel kinetics on rheobase. The Kendall rank correlation (Kendall \(\tau\)) coefficients between shifts in \(V_{1/2}\) and rheobase, slope factor k and AUC as well as maximal current conductances and rheobase for each model are shown on the right in (A), (B) and (C) respectively. The relationships between rheobase and \(\Delta V_{1/2}\), slope (k) and maximal conductance (g) for the Kendall \(\tau\) coefficients highlights by the black box are depicted in the middle panel. The fI curves corresponding to one of the models are shown in the left panels.} + \caption[]{Effects of altered channel kinetics on rheobase. The fI curves corresponding to shifts in FS \(+\)\Kv model \Kv activation \(V_{1/2}\) (A), changes \Kv inactivation slope factor \(k\) in the Cb stellate \(+\)\Kv model (B), and changes in maximal conductance of the leak current in the Cb stellate model (C) are shown. The \drheo of fI curves is plotted against \Kv half activation potential (\(\Delta V_{1/2}\); B), \Kv inactivation slope factor \(k\) (k/\(\textrm{k}_{WT}\); E) and maximal conductance \(g\) of the leak current (g/\(\textrm{g}_{WT}\); H) for all models (thin lines) with relationships from the fI curve examples (A, D, G respectively) highlighted by thick lines with colors corresponding to the box highlighting each set of fI curves. The Kendall rank correlation (Kendall \(\tau\)) coefficients between shifts in half maximal potential \(V_{1/2}\) and \drheo (C), slope factor k and \drheo (F) as well as maximal current conductances and \drheo (I) for each model and current property is computed. The relationships between \(\Delta V_{1/2}\), k/\(\textrm{k}_{WT}\), and g/\(\textrm{g}_{WT}\) and \drheo for the Kendall rank correlations highlighted in the black boxes are depicted in (B), (E) and (H) respectively..} \label{fig:rheobase_correlation} \end{figure}