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some comments to methods

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sonnenberg 2022-05-10 10:59:00 +02:00
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@ -222,10 +222,11 @@ All modelling and simulation was done in parallel with custom written Python 3.8
\subsection*{Different Cell Models} \subsection*{Different Cell Models}
A group of neuronal models representing the major classes of cortical and thalamic neurons including regular spiking pyramidal (RS pyramidal), regular spiking inhibitory (RS inhibitory), and fast spiking (FS) cells were used \citep{pospischil_minimal_2008}. To each of these models, a \Kv current (\IKv; \citealt{ranjan_kinetic_2019}) was added. A cerebellar stellate cell model from \citet{alexander_cerebellar_2019} is used (Cb stellate). This model was also used with a \Kv current \citep{ranjan_kinetic_2019} in addition to the A-type potassium current (Cb stellate +\Kv) or replacing the A-type potassium current (Cb stellate \(\Delta\)\Kv). A subthalamic nucleus neuron model as described by \citet{otsuka_conductance-based_2004} are used (STN) and with a \Kv current (\IKv; \citealp{ranjan_kinetic_2019}) in addition to the A-type potassium current (STN +\Kv) or replacing the A-type potassium current (STN \(\Delta\)\Kv). The properties and conductances of each model are detailed in \Cref{tab:g} and the gating properties are unaltered from the original Cb stellate and STN models. For comparability to typical electrophysiological data fitting reported and for ease of further gating curve manipulations, a Boltzmann function A group of neuronal models representing the major classes of cortical and thalamic neurons including regular spiking pyramidal (RS pyramidal), regular spiking inhibitory (RS inhibitory), and fast spiking (FS) cells were used \citep{pospischil_minimal_2008}. To each of these models, a \Kv current (\IKv; \citealt{ranjan_kinetic_2019}) was added. A cerebellar stellate cell model from \citet{alexander_cerebellar_2019} is used (Cb stellate). This model was also used with a \Kv current \citep{ranjan_kinetic_2019} in addition to the A-type potassium current (Cb stellate +\Kv) or replacing the A-type potassium current (Cb stellate \(\Delta\)\Kv). A subthalamic nucleus neuron model as described by \citet{otsuka_conductance-based_2004} are used (STN) and with a \Kv current (\IKv; \citealp{ranjan_kinetic_2019}) in addition to the A-type potassium current (STN +\Kv) or replacing the A-type potassium current (STN \(\Delta\)\Kv). The properties and conductances of each model are detailed in \Cref{tab:g} and the gating properties are unaltered from the original Cb stellate and STN models. For comparability to typical electrophysiological data fitting reported and for ease of further gating curve manipulations, a Boltzmann function
\notels{is this still a Boltzmann function?}
\begin{equation}\label{eqn:Boltz} \begin{equation}\label{eqn:Boltz}
x_\infty = {\left(\frac{1-a}{1+{\exp\left[{\frac{V-V_{1/2}}{k}}\right]}} +a\right)^j} x_\infty = {\left(\frac{1-a}{1+{\exp\left[{\frac{V-V_{1/2}}{k}}\right]}} +a\right)^j}
\end{equation} \end{equation}
with slope \(k\), voltage for half-maximal activation or inactivation (\(V_{1/2}\)), exponent \(j\), and persistent current \(0 \leq a \leq 1\) were fitted for the RS pyramidal, RS inhibitory and FS models \cite{pospischil_minimal_2008}. The properties of \IKv were fitted to the mean wild type biophysical parameters of \Kv \citep{lauxmann_therapeutic_2021}. with slope \(k\), voltage for half-maximal activation or inactivation (\(V_{1/2}\)), exponent \(j\), and persistent current \(0 \leq a \leq 1\) were fitted for the RS pyramidal, RS inhibitory and FS models \cite{pospischil_minimal_2008} \notels{this reference could be missleading, they didnt't fit these parameters and the model origin is cited above}. The properties of \IKv were fitted to the mean wild type biophysical parameters of \Kv \citep{lauxmann_therapeutic_2021}.
\input{g_table} \input{g_table}