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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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% Ab hier beginnt der eigentliche Text:
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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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\begin{document}
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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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% Titelseite
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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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\begin{titlepage}
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\begin{center}
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{\Huge TITEL \par}
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\vspace{0.75cm}
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{\Large Masterthesis \par}
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\vspace{0.25cm}
|
||||
{der Mathematisch-Naturwissenschaftlichen Fakultät \par} {der Eberhard Karls Universität Tübingen \par}
|
||||
\vspace{0.75cm}
|
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{Erstkorrektor: \\
|
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Zweitkorrektor: Prof.~Dr.~Jan Benda \par}
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\vspace{0.25cm}
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||||
{Lehrbereich für Neuroethologie}
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\vfill
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\large vorgelegt von \par
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\large Alexander Mathias Ott \par
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Abgabedatum: 30.11.2017
|
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\end{center}
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\end{titlepage}
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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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% Erklärung
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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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||||
\section*{Eigenständigkeitserklärung}
|
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|
||||
\vspace{0.5cm}
|
||||
|
||||
Hiermit erkläre ich, dass ich die vorgelegte Arbeit selbstständig verfasst habe und keine anderen als die angegebenen Quellen und Hilfsmittel benutzt habe.
|
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\vspace{2mm}
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\noindent
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Außerdem erkläre ich, dass die eingereichte Arbeit weder vollständig noch in wesentlichen Teilen Gegenstand eines anderen Prüfungsverfahrens gewesen ist.
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\vfill
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\begin{tabular}{ll}
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$\overline{\text{Unterschrift}\hspace{6cm}}$ & $\overline{\text{Ort, Datum}\hspace{4cm}}$ \\
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\end{tabular}
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\newpage\newpage
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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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% Inhalsverzeichnis
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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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{
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\hypersetup{linkcolor=black}
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\tableofcontents
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}
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||||
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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||||
% Zusammenfassung
|
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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
|
||||
\section{Abstract}
|
||||
%Einleitung + Ergebnisse der Diskussion in kurz
|
||||
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||||
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||||
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||||
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
|
||||
% Einleitung
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||||
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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||||
\section{Introduction}
|
||||
|
||||
\begin{enumerate}
|
||||
\item electric fish
|
||||
\begin{enumerate}
|
||||
\item general: habitat,
|
||||
\item as model animal for ethology
|
||||
\item electric organ + eod
|
||||
\item sensory neurons p- and t(?)-type
|
||||
\end{enumerate}
|
||||
\item sensory perception
|
||||
\begin{enumerate}
|
||||
\item receptor -> heterogenic population
|
||||
\item further analysis limited by what receptors code for
|
||||
\item p-type neurons code AMs
|
||||
\end{enumerate}
|
||||
|
||||
\item goal be able to simulate heterogenic population to analyse full coding properties -> many cells at the same time needed -> only possible in vitro/ with model simulations
|
||||
|
||||
\item Possible to draw representative values for model parameters to generate a population ?
|
||||
|
||||
|
||||
\end{enumerate}
|
||||
|
||||
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
|
||||
% Methoden
|
||||
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
|
||||
\section{Materials and Methods}
|
||||
|
||||
\subsection{Notes:}
|
||||
|
||||
\begin{enumerate}
|
||||
|
||||
\item Construction of model
|
||||
\begin{enumerate}
|
||||
\item Explain general LIF
|
||||
\item parameters explanation, dif. equations
|
||||
\item Explain addition of adaption current
|
||||
\item note addition of noise
|
||||
\item check between alpha in fire-rate model adaption and a-delta in LIFAC
|
||||
\item check for noise independence from step-size (?)
|
||||
\end{enumerate}
|
||||
|
||||
\item Data generation
|
||||
\begin{enumerate}
|
||||
\item How data was measured / which data used
|
||||
\item How data was chosen -> at least 30s baseline, 7 contrasts with 7 trials
|
||||
\item experimental protocells were allowed by XYZ (before 2012: All experimental protocols were approved and complied with national and regional laws (file no. 55.2-1-54-2531-135-09). between 2013-2016 ZP 1/13 Regierungspräsidium Tübingen and after 2016 ZP 1/16 Regierungspräsidium Tübingen)
|
||||
\end{enumerate}
|
||||
|
||||
\item behavior parameters:
|
||||
\begin{enumerate}
|
||||
\item which behaviors were looked at / calculated and why (bf, vs, sc, cv, fi-curve...)
|
||||
\item how exactly were they calculated in the cell and model
|
||||
\end{enumerate}
|
||||
|
||||
\item Fitting of model to data
|
||||
\begin{enumerate}
|
||||
\item which variables where determined beforehand (None, just for start parameters)
|
||||
\item which variables where fit
|
||||
\item What method was used (Nelder-Mead) and why/(how it works?)
|
||||
\item fit routine ? (currently just all at the same time)
|
||||
\end{enumerate}
|
||||
\end{enumerate}
|
||||
|
||||
|
||||
\section{Results}
|
||||
|
||||
\begin{enumerate}
|
||||
|
||||
\item how well does the fitting work?
|
||||
|
||||
\item distribution of behavior parameters (cells and models)
|
||||
|
||||
\item distributions of parameters
|
||||
|
||||
\item correlations: between parameters between parameters and behavior
|
||||
|
||||
\item correlation between final error and behavior parameters of the cell -> hard to fit cell types
|
||||
|
||||
\item (response to SAM stimuli)
|
||||
\end{enumerate}
|
||||
|
||||
|
||||
\section{Discussion}
|
||||
|
||||
|
||||
|
||||
\section{Possible Sources}
|
||||
|
||||
\subsection{Henriette Walz - Thesis}
|
||||
\subsubsection{Nervous system - Signal encoding}
|
||||
\begin{enumerate}
|
||||
\item single neurons are the building blocks of the nervous system (Cajal 1899)
|
||||
\item encoding of information in spike frequency - rate code(first description(?) Adrian 1928) also find examples! (light flash intensity Barlow et al. 1971, )
|
||||
\item encoding info in inter spike intervals (Singer and Gary 1995)
|
||||
\item encoding time window (Theunissen and Miller 1995) "This time window is the time scale in which the encoding is assumed to take placewithin the nervous system
|
||||
\item encoding is noisy (Mainen and Sejnowski 1995, Tolhurst et al 1983, Tomko and Crapper 1974 -> review Faisal et al 2008) in part because of stimulus properties but also cell properties (Ion channel stochasticity (van Rossum et al.,2003))
|
||||
\item noise can be beneficial to encoding -> “stochastic
|
||||
resonance” (weak stimuli on thresholding devices like neurons, noice allows coding of sub threshold stimuli) (Benzi et al., 1981)
|
||||
\end{enumerate}
|
||||
|
||||
|
||||
\end{document}
|
||||
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|
||||
\contentsline {section}{\numberline {1}Abstract}{2}{section.1}
|
||||
\contentsline {section}{\numberline {2}Introduction}{2}{section.2}
|
||||
\contentsline {section}{\numberline {3}Materials and Methods}{2}{section.3}
|
||||
\contentsline {subsection}{\numberline {3.1}Notes:}{2}{subsection.3.1}
|
||||
\contentsline {section}{\numberline {4}Results}{3}{section.4}
|
||||
\contentsline {section}{\numberline {5}Discussion}{3}{section.5}
|
||||
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